I don't consider beads flies, but Simm's posts on beads clear some smoke from this sport. One does not need to have 6000 flies including 5 stages of each common Eastern hatch and 2 or 3 stages of the rarer ones plus a wet fly box, a streamer box, a junk fly box, and a box for each month of the year to catch lots of fish.
You can keep it simple, even though few of us can resist the lure of carrying at least 12 lbs of flies with us at all times.
Dark parachute dry fly, light parachute mayfly, a brown bugger, and some pheasant tails probably will do it.
I like chamois worms and sucker spawn. Maybe a Walt's Worm or two. Prince nymphs in the fall. Rusty spinners in the evening. Big ugly streamers in high water. Usuals in cadis waters. Zebra midges, RS2s, red midge larvae, Al's Rats etc when they are taking small stuff. Rainbow warriors seem to work almost all the time and I wouldn't go to a limestoner without a few scuds. Pretty soon I am drowning in flies.